Deproteinized Natural Rubber Latex/Hydroxypropylmethyl Cellulose Blending Polymers for Nicotine Matrix Films
Wiwat Pichayakorn, Jirapornchai Suksaeree, Prapaporn Boonme, Thanaporn Amnuaikit, Wirach Taweepreda, Garnpimol C. Ritthidej
Industrial & Engineering Chemistry Research · 2012
Nicotine matrix films were prepared using DNRL/HPMC blends for transdermal delivery. Several plasticizers were also mixed. The mechanical and physicochemical properties, moisture uptake, and swelling ratio of films depended on HPMC and plasticizers. The compatibility of each ingredient in the blended films was confirmed by FT-IR, XRD, and DSC. The in vitro release of nicotine showed a monophasic slow release pattern. The polymer and plasticizer blends produced a faster release rate. The kinetics of nicotine release from the films fitted the diffusion type. Surprisingly, the permeation of the nicotine into the skin occurred by zero-order kinetics. It was concluded that nicotine matrix films could be produced that could provide a controlled release of the drug and suitable permeation patterns. Moreover, they were safe to apply to the skin as they did not cause irritation.